Unexplained causes of recurrent miscarriages?

The presence of two or more pregnancy losses under 20 weeks is defined as recurrent pregnancy loss. Research has shown that the underlying causes of miscarriages may include genetic problems, uterine-related pathologies, endocrine organ diseases such as thyroid and diabetes, coagulation disorders and consumption of toxic substances such as cigarettes. However, these causes account for only half of the cases of recurrent pregnancy loss. As a result of studies carried out at the molecular and genetic level, especially in recent years, it has been determined that the immunological structure of couples, that is, the immune system, may be one of the main reasons underlying recurrent miscarriages and that the 'immune system' may play a key role. especially in the presence of undetermined losses. The most important reason for the definition of this rather new concept is the molecular level studies showing that pregnancy in couples creates a barrier system in the womb that will protect the mother from defense systems and ensure her nutrition and growth. As a result of such genetic studies, it is thought that the mother's immune response, both at the systemic and uterine level, is very important for the continuation of pregnancies, and the development of treatment plans in this regard will positively affect the pregnancy.